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Spikes are a universal hazard in various Neutronized games. They usually jut out of certain platforms or other forms of ground, and are always in areas where the main character is at risk of making contact with. While spikes themselves do not move, they may be situated in an area beneath them which moves.

These hazards must be avoided, no matter which game is played. If the player moves their character into spikes, the character takes a certain amount of damage, depending on the game. In most cases, the character only loses a portion of their health, usually a heart or a bar of health. With the exception of Dyna Boy in which spikes can be destroyed by TNT, spikes cannot be destroyed.